![]() "Considering the pattern of functional and structural connectivity of the brain, regional changes are frequently associated with alterations in remote areas of the brain which will not be captured in a ROI analysis. ![]() "ROI analyses compress a complex signal pattern into a regional average, thus losing the anatomical specificity of the structural data obtained," Draganski tells Medical Xpress. The scientists face a number of challenges when conducting their study, the first being using a whole-brain approach to resolve ambiguities in region-of-interest (ROI) imaging studies in ECT treatment of mood disorders. Juergen Dukart and their co-authors published in Proceedings of the National Academy of Sciences. Bogdan Draganski discussed the paper that he, Dr. Since interaction between ECT and specific pathology appears to be therapeutically causal, the researchers state that their results have implications for deep brain stimulation, transcranial magnetic stimulation and other electrically-based brain treatments. ![]() Recently, however, scientists at Université de Lausanne, Lausanne, Switzerland and Charité University Medicine, Berlin, Germany found local but not general anatomical brain changes following electroconvulsive therapy that are differently distributed in each disease, and are actually the areas believed to be abnormal in each disorder. The scientific, clinical, and ethical controversy extends to unanswered questions about its precise mechanism of action – that is, how major electrical discharge over half the brain shows efficacy in recovery from a range of sometimes quite distinct psychological and psychiatric disorders. ![]() (Medical Xpress)-The oldest well-established procedure for somatic treatment of unipolar and bipolar disorders, electroconvulsive therapy (ECT) has, at best, a variegated reputation – and not just in its reputation for being a "barbaric" treatment modality (which, as it turns out, it is not). ECT given at any time point if clinically indicated. Schematic representation of study design and statistical analyses. ![]()
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